Dietary-based gut flora modulation against Clostridium difficile onset

Clostridium difficile infection is a frequent complication of antibiotic therapy in hospitalised patients, which today is attracting more attention than ever and has led to its classification as a 'superbug'. Disruption of the composition of the intestinal microflora following antibiotic treatment is an important prerequisite for overgrowth of C. difficile and the subsequent development of an infection. Treatment options for antibiotic-associated diarrhoea and C. difficile-induced colitis include administration of specific antibiotics (e.g. vancomycin), which often leads to high relapse rates. More importantly, both the rate and severity of C. difficile-associated diseases are increasing, with new epidemic strains of C. difficile often implicated. For the prevention and treatment of antibiotic-associated diarrhoea and C. difficile infection, several probiotic bacteria such as selected strains of lactobacilli (especially Lactobacillus rhamnosus GG), Bifidobacterium longum, and Enterococcus faecium and the non-pathogenic yeast Saccharomyces boulardii have been used. Controlled trials indicate a benefit of S. boulardii and L. rhamnosus GG as therapeutic agents when used as adjuncts to antibiotics. However, the need for more well designed controlled trials with probiotics is explicit

Energy, carbon and cost performance of building stocks : upgrade analysis, energy labelling and national policy development

The area of policy formulation for the energy and carbon performance of buildings is coming under increasing focus. A major challenge is to account for the large variation within building stocks relative to factors such as location, climate, age, construction, previous upgrades, appliance usage, and type of heating/cooling/lighting system. Existing policy-related tools that rely on simple calculation methods have limited ability to represent the dynamic interconnectedness of technology options and the impact of possible future changes in climate and occupant behaviour. The use of detailed simulation tools to address these limitations in the context of policy development has hitherto been focussed on the modelling of a number of representative designs rather than dealing with the spread inherent in large building stocks. Further, these tools have been research-oriented and largely unsuitable for direct use by policy-makers, practitioners and, ultimately, building owners/occupiers. This paper summarises recent initiatives that have applied advanced modelling and simulation in the context of policy formulation for large building stocks. To exemplify the stages of the process, aspects of the ESRU Domestic Energy Model (EDEM) are described. EDEM is a policy support tool built on detailed simulation models aligned with the outcomes of national surveys and future projections for the housing stock. On the basis of pragmatic inputs, the tool is able to determine energy use, carbon emissions and upgrade/running cost for any national building stock or sub-set. The tool has been used at the behest of the Scottish Building Standards Agency and South Ayrshire Council to determine the impact of housing upgrades, including the deployment of new and renewable energy systems, and to rate the energy/carbon performance of individual dwellings as required by the European Commission's Directive on the Energy Performance of Buildings (EC 2002)

The EDEM methodology for housing upgrade analysis, carbon and energy labelling and national policy development

The ESRU Domestic Energy Model (EDEM) has been developed in response to demand from policy makers for a tool to assist in analysis of options for improving carbon and energy performance of housing across a range of possible future technologies, behaviours and environmental factors. A major challenge is to comprehend the large variation in fabric, systems (heating, hot water, lighting and appliances) and behaviours across the housing stock as well as uncertainty over future trends. Existing static models have limited ability to represent dynamic behaviour while use of detailed simulation has been based on modelling only a small number of representative designs. To address these challenges, EDEM has been developed as an easy to use, Web based tool, built on detailed simulation models aligned with national house survey data. From pragmatic inputs, EDEM can determine energy use and carbon emissions at any scale, from individual dwelling to national housing stock. EDEM was used at the behest of the Scottish Building Standards Agency and South Ayrshire Council to quantify the impact of upgrades including new and renewable energy systems. EDEM was also used to rate energy/carbon performance of dwellings as required by the EU Directive (EU, 2002). This paper describes the evolving EDEM methodology, its structure and operation then presents findings from applications. While initial EDEM projects have been for the Scottish housing stock the methodology is structured to facilitate project development and application to other countries

The role of built environment energy efficiency in a sustainable UK energy economy

Energy efficiency in the built environment can make significant contributions to a sustainable energy economy. In order to achieve this, greater public awareness of the importance of energy efficiency is required. In the short term, new efficient domestic appliances, building technologies, legislation quantifying building plant performance, and improved building regulations to include installed plant will be required. Continuing these improvements in the longer term is likely to see the adoption of small-scale renewable technologies embedded in the building fabric. Internet-based energy services will see low-cost building energy management and control delivered to the mass market in order that plant can be operated and maintained at optimum performance levels and energy savings quantified. There are many technology options for improved energy performance of the building fabric and energy systems and it's not yet clear which will prove to be the most economic. Therefore, flexibility is needed in legislation and energy-efficiency initiatives

Considerations for Research Funders and Managers to Facilitate the Translation of Scientific Knowledge into Practice

Research funders and managers can play a critical role in supporting the translation of knowledge into action by facilitating the brokering of knowledge and partnerships. We use semi-structured interviews with a research funding agency, the Australian Centre for International Agricultural Research (ACIAR), to explore (i) ways that funders can facilitate knowledge brokering, the (ii) barriers to, and (iii) enablers for, facilitating knowledge brokering, and (iv) the individual skills and attributes for research program funders and managers to be effective brokers. Based on these findings, we generate three considerations for research funders elsewhere, in particular R4D funders, seeking to build capacity for knowledge brokering: (i) formalise the process and practice, (ii) develop shared language and understanding, and (iii) build individual competencies and capabilities. Our findings complement the existing literature with a context specific analysis of how research funders can facilitate knowledge brokering, and by identifying the barriers and enablers in doing so

Linking Hydro-Geophysics and Remote Sensing Technology for Sustainable Water and Agricultural Catchment Management

PosterThe acquisition of sub-surface data for agricultural purposes is traditionally achieved by in situ point sampling in the top 2m over limited target areas (farm scale ~ km2) and time periods. This approach is inadequate for integrated regional (water catchment ~ 100 km2) scale management strategies which require an understanding of processes varying over decadal time scales in the transition zone (~ 10’s m) from surface to bedrock. With global food demand expected to increase by 100% by 2050, there are worldwide concerns that achievement of production targets will be at the expense of water quality. In order to overcome the limitations of the traditional approach, this research programme will combine airborne and ground geophysics with remote sensing technologies to access hydrogeological and soil structure information on Irish Soils at multiple spatial scales. It will address this problem in the context of providing tools for the sustainable management of agricultural intensification envisioned in Food Harvest 2020 and Food Wise 2025 and considering the EU Habitats and Water Framework Directives (WFD), Clean Air Policy and Soil Thematic Strategies. The work will use existing ground based geophysical and hydrogeological data from Teagasc Agricultural Catchment Programme (ACP) and Heavy Soil sites co-located ground and airborne electromagnetic data. Neural Networks training and Machine learning approaches will supplement traditional geophysical workflows. Work will then focus on upscaling results from ACP to WFD catchment scale. This upscaling will require modification of traditional satellite remote sensing conceptual frameworks to analyse heterogeneous, multi-temporal data streams